Treatment of vertical root fracture using hybrid between TCP resin composits and nanohydroxyapatite collagen

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462867
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Hokkaido University
• Principal Investigator: SUGAYA Tsutomu 北海道大学, 歯学研究科, 准教授 (10211301)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 垂直歯根破折 / 樹脂含侵層 / BMP / 硬組織再生 / レジン

Outline of Final Research Achievements

Induction of ectopic hard tissue formation and resin-bonding affinity using αTCP-4META/MMA-TBB resin composits and ascorbic acid/copper chloride or EDC crosslinked nanohydroxyapatite/collagen complex (nHAC)　impregnated with BMP-2 were examined in vitro and in vivo in order to improve the clinical outcome of vertical root fracture treatent.
As results, a hybrid layer was observed at the interface between resin and bone in both optical microscope and SEM observation, and direct resin-bone contact was observed without connective tissue intervention, when nHAC crosslinked with ascorbic acid/copper chloride was adhered to resin and impregnated with BMP-2 and implanted into connective tissue.

Free Research Field

歯周病学