2016 Fiscal Year Final Research Report
The development of a novel preventive method of periodontal disease using S-PRG Filler eluate
| Project/Area Number |
26462871
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI OSAMU 東北大学, 大学院歯学研究科, 教授 (60374948)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | Periodontal disease / Bone loss / Inflammation / S-PRG filler |
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| Outline of Final Research Achievements |
S-PRG filler, a component of composite resin, is capable of releasing 6 metal ions that possess antibacterial activity against caries and periodontal pathogens. Although S-PRG has been suggested to be involved in oral disease prevention, no reports have been published regarding its preventive effect on periodontal disease in vivo. The present study investigated whether the eluate from S-PRG (S-PRG eluate) has a preventive effect on a mouse model of ligature-induced periodontal disease.
C57BL/6 mice were divided into three groups; no ligature, ligature and ligature with S-PRG eluate group. S-PRG eluate clearly inhibited alveolar bone loss of ligature-induced periodontal disease and reduced the infiltration of inflammatory cells. TOF-SIMS analysis revealed that more boron ions were present in the S-PRG group. Our results suggest that the S-PRG eluate has a preventive effect against tissue destruction in periodontal disease through its anti-inflammatory effects in vivo.
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| Free Research Field |
医歯薬学
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