2016 Fiscal Year Final Research Report
Paradigm shift of strategies for the control of oral biofilm and a novel antibiofilm chemotherapy targeting exopolysaccharide synthesis.
| Project/Area Number |
26462876
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | バイオフィルム / 化学的コントロール / 分散 / 剥離 / 共焦点レーザー顕微鏡 |
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| Outline of Final Research Achievements |
Chemical complements such as toothpaste and mouthrinses that contain antimicrobial agents have proven to be effective for the control of oral biofilm. However, we have demonstrated some adverse effects of antimicrobial agents. One adverse effect is that most of the antimicrobial agents failed to remove the biofilm structure. The residual structure may serve as a scaffold for the redevelopment of biofilm. Another effect is that low-dose antibiotics may promote bacterial biofilm formation. Taken together, future strategies that promote the biofilm matrix detachment are expected, without affecting bacterial growth targeting to polymeric substances.
We have developed a novel antibiofilm chemotherapy targeting exopolysaccharide synthesis. Vizantin, a recently developed immunostimulating compound, possessed antibiofilm activity against Streptococcus mutans without affecting bacterial growth. This compound causes S. mutans biofilm to detach by altering its internal architecture.
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| Free Research Field |
歯科保存学
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