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2016 Fiscal Year Final Research Report

Multi-faceted analysis of cause investigation on refractory periapical periodontitis

Research Project

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Project/Area Number 26462880
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Conservative dentistry
Research InstitutionOsaka University

Principal Investigator

NAGAYAMA TOMOTAKA  大阪大学, 歯学研究科, 招聘教員 (60456944)

Co-Investigator(Renkei-kenkyūsha) ASAHI YOKO  大阪大学, 大学院歯学研究科, 助教 (50456943)
Project Period (FY) 2014-04-01 – 2017-03-31
Keywords歯内療法学 / 細菌 / バイオフィルム / 難治性根尖性歯周炎 / 16s rRNA遺伝子解析法 / CBCT / 咬合性外傷
Outline of Final Research Achievements

To clarify the cause of refractory periapical periodontitis, bacterial biofilm on root apex obtained by apicoectomy or tooth extraction was investigated by PCR-based 16s rRNA gene assay. In addition, we performed morphologically examination by scanning electron microscope and clinical examination in oreder to analyze pathology from both the basic and clinical aspects. As a result, we demonstrated the various patterns of pathology on refractory periapical periodontitis conbined with multiple factors such as the 3D shape of apical lesion, anatomical form of root apex and occlusal trauma in addition to extraradicular biofilm.

Free Research Field

歯科保存学

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Published: 2018-03-22  

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