2016 Fiscal Year Final Research Report
Establishment of dental pulp preservation therapy using histone deacetylase inhibitor
| Project/Area Number |
26462891
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | エピジェネティクス / 歯髄保存療法剤 / 修復組織形成 |
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| Outline of Final Research Achievements |
Calcium hydroxide agents have been widely used as pulp conservative treatment. Some improvements are required for the better quality of the formed dentin and the shorter times to dentin formation. Histone deacetylase inhibitors (HDACi) involved in epigenetic modifications promoted osteoblastic differentiation and inhibited osteoclast differentiation. In this study, we examined whether HDACi promoted odontoblast differentiation in vitro. The results indicate that HDACis may promote differentiation of odontoblastic cells and induce their calcification. Some of HDACis may be useful agents for pulp conservative treatment.
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| Free Research Field |
医歯薬学
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