2016 Fiscal Year Final Research Report
Development of metal nanoparticles contained resin material that inhibit MMP activity
| Project/Area Number |
26462953
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Osaka University |
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Principal Investigator |
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| Research Collaborator |
Kawakami Hayato
Kawai Koji
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ナノ粒子 / MMP阻害剤 / 細胞毒性 |
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| Outline of Final Research Achievements |
This study evaluated the inhibition of MMPs and toxicity of nanoparticles (NPs) as possible compounds for use in dental adhesives. The MMP assay for studying the interaction of MMPs and nanoparticles (NPs) was evaluated. The cellular responses to NPs were examined using cytotoxic assay. The mechanical properties of the experimental resin loaded with NPs were examined using thermomechanical analysis. Many NPs inhibited MMP activity at relatively low concentrations. The NPs inhibit MMPs by chelating with the Zn2+ bound in the active sites of MMPs. The mechanical properties of the resins increased when NPs were added in resins. NPs are attractive candidates for dental materials to inhibit MMPs and improve the mechanical properties of resins without cytotoxic effects to cells.
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| Free Research Field |
歯科理工学
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