2016 Fiscal Year Final Research Report
A study for establishment of new periodontal/bone regenerative therapy by using BMP-9
| Project/Area Number |
26462972
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | BMP-9 / 歯周病 / 骨再生 / 歯周組織再生 / 歯根膜細胞 |
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| Outline of Final Research Achievements |
Periodontitis is an inflammatory disease resulting in tooth loss in patients. Further progress is needed in regeneration-based treatment of periodontal disease. In this study, basic research on periodontal regenerative therapy using bone morphogenetic protein (BMP)-9 was performed. As a result, (1) rhBMP-9 potently induces osteoblastic differentiation of human periodontal ligament (PDL) fibroblasts as compared with rhBMP-2. (2)rhBMP-9/ACS provided comparable new bone formation to rhBMP-2/ACS with less adipose tissues after a healing period of 8 weeks in rat calvarial critical-size defects. Further research investigating the potential of rhBMP-9 as a therapeutic agent for future oral and periodontal reconstructive procedures and medical fields is still necessary, and mechanisms underlying the effects of rhBMP-9 on periodontal/bone regeneration must be elucidated prior to clinical use in humans.
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| Free Research Field |
歯周病学
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