Does Advanced Glycation End products (AGEs) is useful for risk management of implant treatment ?

2016 Fiscal Year Final Research Report

• Project/Area Number: 26462977
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Tokyo Dental College
• Principal Investigator: Sasaki Hodaka 東京歯科大学, 歯学部, 講師 (50433959)
• Co-Investigator(Renkei-kenkyūsha): MORI Gentaro 東京歯科大学, 歯学部, 助教 (30733745)
• Research Collaborator: KOBAYASHI Takaumi 東京歯科大学, 歯学部, 大学院生
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: インプラント / 終末糖化産物 / 糖尿病モデルラット / ＡＧＥｓ

Outline of Final Research Achievements

Recently, Advanced Glycation End products (AGEs) known to accumulate in bone collagen by diabetes mellitus was reported to have a relationship with reduction of bone quality. However, it was not clarified the correlation between accumulation of AGEs and implant treatment success due to established osseointegration. The aim of this study was to investigate the effect of accumulation of AGEs during osseointegration using diabetes mellitus model rats. There were no significant deafferents between new bone formation in the bone defect area and around implant body of experimental group and those of control groups. On the other hands, positive immunoreaction of AGEs was recognized at the implant neck area of cortical bone in experimental group. From those result, accumulation of AGEs does not have relationship with early stage of osteointegration. However, AGEs is suggest to effect the long-term success rate, because implant neck area was known to be starting point of peri-implantitis.

Free Research Field

口腔インプラント