Development of zinc sustained-release titanium framework to promote the proliferation and differentiation of osteoblasts

2017 Fiscal Year Final Research Report

• Project/Area Number: 26462993
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Akita University
• Principal Investigator: FUKUDA MASAYUKI 秋田大学, 医学部, 准教授(病院教授) (20272049)
• Co-Investigator(Kenkyū-buntansha): 山本 修 山形大学, 大学院理工学研究科, 教授 (00230540) ; 高野 裕史 秋田大学, 医学部, 講師 (30282172)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 顎骨再建 / 亜鉛 / チタン / フレームワーク

Outline of Final Research Achievements

We investigated the effect of promoting the differentiation and proliferation of osteoblasts by preparing a zinc sustained-release titanium (Zn-Ti) framework by modifying zinc complex on titanium surface.　It was found that the Zn-Ti mesh can release zinc ions in a sustained manner, and this zinc ion differentiates and proliferates the cells surrounding the material into osteoblasts and further promotes mineralization. In bone formation ability experiments in which bone defects prepared in the rat skull were coated with Zn-Ti mesh, there was a difference in bone regeneration rate between Ti and Zn-Ti used for control, but statistical no significant difference was obtained.

Free Research Field

口腔外科学