2016 Fiscal Year Final Research Report
Regeneration of muscle by introduction of MyoD family gene into adipose-derived stem cells
| Project/Area Number |
26462994
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | MyoD family 遺伝子 / 脂肪幹細胞 / 筋再生 |
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| Outline of Final Research Achievements |
Myocutaneous flaps are clinically used for reconstruction of tissue defect, which is caused by the operations for oral cancer. However, restricted movement and power reduction of muscle frequently occurred. In this study, we tried to regenerate muscle cells from several kinds of cells, such as human adipose derived stem cell, human fatal fibroblast, and human bone marrow stem cell, by induction of MyoD family and Pax-7 genes, which are important for muscle differentiation. In the transfectants, α-actinin and α-SMA, two specific markers of myogenesis, were detected, suggesting that MyoD family and Pax-7 genes might be important factors of regeneration of muscle.
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| Free Research Field |
医歯薬学 歯学・外科系歯学
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