2016 Fiscal Year Final Research Report
Nicotine Induces Lymph Node Metastasis of Oral Cancer Cells through EGFR Activation
| Project/Area Number |
26463004
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
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| Research Collaborator |
Hassan Mohammad Monsur Charles Sturt University, School of Dentistry & Health Sciences
Hu Guo-Fu Molecular Oncology Research Institute, Tufts Medical Center
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ニコチン |
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| Outline of Final Research Achievements |
Nicotine, which is one of the main component of tobacco, is absorbed from oral mucosa and pulmonary alveoli by smoking, and moves to blood. Nicotine in blood binds to nicotinic acetylcholine receptor (nAChR) in central nervous system and relates to tobacco addiction. Recently, it has been reported that nicotine promotes proliferation and invasion in breast cancer cells through epidermal growth factor receptor (EGFR) activation. However, the role of nicotine in oral cancer cells is still unknown although oral cavity is most exposed organ to tobacco smoke. Therefore, this study assessed the effects of nicotine on oral cancer cells. Nicotine increased lymph node metastasis of oral cancer cells in animal model.The mechanism underlying the tumor progressive effects of nicotine in oral cancer cells consists of upregulation of cell proliferation, migration and invasion via the activation of EGFR.
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| Free Research Field |
口腔外科
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