Purification, structure characterization of bioactive substances from marine organisms and application them to novel anti-oral cancer drugs with iPS cell research technique

2016 Fiscal Year Final Research Report

• Project/Area Number: 26463006
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Hiroshima University
• Principal Investigator: Yukio YOSHIOKA 広島大学, 医歯薬保健学研究院(歯), 助教 (20335665)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 海洋生物 / 細胞毒性 / 抗腫瘍効果 / 扁平上皮癌細胞 / 無血清培養 / ヒトiPS細胞 / 創薬

Outline of Final Research Achievements

Marine organisms have some different systems of metabolism and physiological functions from the living thing on the ground. We extract the bioactive substances from them and isolate the substances with the strong antitumor activity for the index of the cytotoxicity against cancer cells. We aim not only to analyze the antitumor effect for oral squamous cell carcinoma cells but also apply them to the novel antitumor agents against oral cancer. Marine organisms from both adjacent Japanese sea and adjacent Indonesian sea are collected and freeze-dried. The extracted compounds are investigated their activity by cytotoxic assay for cancer cells and are purified.The novel bioactive substances are investigated with the toxicity for the human iPS cells which are differentiated into some important organic cells under the serum free culture.

Free Research Field

口腔外科学