2016 Fiscal Year Final Research Report
The choice of the suitable regenerated substitutive bone to the defect of jaw bone
| Project/Area Number |
26463022
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 未分化間葉系細胞 / 凍結保存 / 再生医工学 |
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| Outline of Final Research Achievements |
By the animal experiment of the skull defect model, that amount of ossification became the following order: scaffold,< supernatant +scaffold, <supernatant (10X) +scaffold, < hBMC+scaffold. From this result、we thought that the bone regeneration therapy by using mesenchymal cells would be limited to the bone defect for which the continuous growth factors were needed. According to the circumstances (a general status, age, base conditions, etc.) of the bone defect of recipient, it was suggested that we could select the hybird type bone substitute, for example conditioned medium alone or a concentrated conditioned medium, further hBMC.
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| Free Research Field |
口腔外科学
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