2016 Fiscal Year Final Research Report
Development of pathogenic activity of pemphigus using transgenic mice
| Project/Area Number |
26463023
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KATO Shin 慶應義塾大学, 医学部, 助教 (80383719)
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| Research Collaborator |
KODAKA Rie
FUJITA Kohei
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 自己免疫疾患 / 自己抗体 / 病原性 / 天疱瘡 / 口腔 |
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| Outline of Final Research Achievements |
Pemphigus is an autoimmune blistering disease of skin and oral mucosa. The all of patients with pemphigus vulgaris have a blister in oral mucosa. Many of cases, pathogenic activity of the autoantibody correlate with clinical phenotype of the pemphigus, and it is confirmed their correlation. However, there are many cases that severity of clinical phenotype does not correlate with antibody titers. Therefore, we tried to develop a novel system to measure the pathogenic activity of the pemphigus autoantibody in this study.
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| Free Research Field |
口腔粘膜疾患
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