2016 Fiscal Year Final Research Report
Role of cystatin in salivary secretion
| Project/Area Number |
26463027
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Research Collaborator |
Yoshino Yoko
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | シェーグレン症候群 / シスタチン / 唾液分泌 / アポトーシス / 自己免疫疾患 |
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| Outline of Final Research Achievements |
The purpose of this study was to clarify the role of cystatin in the salivary secretion observed in a Sjogren's syndrome patient.
The secretion of salivary cystatin significantly decreased in the Sjogren's syndrome patient significantly. In Sjogren's syndrome patients, there were many TUNEL positive cells tend to be observed in the serous and mucous acinar cells of the labial glands. The more morphological change that is observed, the less cystatin S intensity that is seen in the serous demilunes of the salivary gland. TheAn inhibition of apoptosis was observed when cystatin S was added to the apoptosis-induced cultured HSG cells.
These results suggested that one of the causes of hyposalivation in Sjogren's syndrome is likelywas the failure of the apoptotic control function by cystatin, and thus the administration of applying cystatin S may have allowed the patient to overcome this problempossibly controlled the failure.
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| Free Research Field |
口腔外科
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