2016 Fiscal Year Final Research Report
Development of minimum-invasive oral cancer therapy using photo-immunotherapy targeted on cancer stem cells
| Project/Area Number |
26463028
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Research Collaborator |
UMEKI Yasuchika
TADOKORO Susumu
TAKEBE Yusuke
YOKOTA Toshio
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 口腔癌 / 低侵襲治療 / 光線免疫療法 / がん幹細胞 / 標的癌治療 |
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| Outline of Final Research Achievements |
The aim of this research was to develop photo-immunotheray (PIT) targeting in cancer stem cells of oral cancer. The equipment for irradiation of near-infrared light and the phthalocyanine-anti CD44v9 antibody composite (F-antiCD44v9) were prepared. We performed the PIT using F-antiCD44v9 on human oral observed that PIT destroyed the cell membrane of cancer cells by PIT. However, PIT did not have anti-tumor effect on the cancer cells which forms the spheroids like a solid cancer.
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| Free Research Field |
口腔外科
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