Genome-wide screening of epigenetic abnormalities which are related with the prognosis of patients with HPV related oral cancers

2016 Fiscal Year Final Research Report

• Project/Area Number: 26463037
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: The University of Tokyo
• Principal Investigator: Abe Masanobut 東京大学, 保健・健康推進本部, 講師 (10392333)
• Co-Investigator(Renkei-kenkyūsha): ABE Takahiro 東京大学, 医学部附属病院顎口腔外科・歯科矯正歯科, 特任講師 (20383250)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: HPV

Outline of Final Research Achievements

The goal of this study was to determine the epigenetic differences between human papilloma virus (HPV)-positive and HPV-negative oral squamous cell carcinomas (OSCCs). For the number of 92 surgical specimens; OSCC(n=49), oral leukoplakia(n=37), oral lichen planus (n=2), Oral intraepithelial neoplasia (n=4), the infectious status of HPV (6, 11, 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, 82) were analyzed by PCR. However, HPV infection was not observed at all in any samples. The of HPV infection in oral cancers are considered to be quite rare unlike oropharyngeal carcinomas.

Free Research Field

口腔癌