Analysis on glycogen metabolism in oral squamous cell carcinoma

2016 Fiscal Year Final Research Report

• Project/Area Number: 26463040
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Shinshu University
• Principal Investigator: KURITA Hiroshi 信州大学, 学術研究院医学系, 教授 (10273103)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: グリコーゲン / 口腔扁平上皮癌 / 代謝 / 解糖系

Outline of Final Research Achievements

It is thought that the glycogen is one of key sources in supplying energy, nucleic acid, and lipid necessary for cancer cell proliferation in oral squamous cell carcinoma. The purpose of this study is to analyze metabolism of glycogen and to elucidate metabolism abnormality in oral squamous cell carcinoma. The results of this study suggested that oral squamous cell carcinoma cell got energy not simply in the glycolytic pathway, a simple course called the glycogen → glucose → glycolytic pathway, and they also suggested the possibility that oral squamous cell carcinoma might get energy by amino acid metabolism. It will be necessary to examine the metabolism of amino acid, glucuronic acid, and nucleic acids etc., and to analyze the specificity in the metabolism of oral squamous cell carcinoma.

Free Research Field

口腔外科学