Establishment of the new oral cancer treatment strategy by elucidation of the lymph node metastasis mechanism

2016 Fiscal Year Final Research Report

• Project/Area Number: 26463047
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Ehime University
• Principal Investigator: Goda Hiroyuki 愛媛大学, 医学部附属病院, 講師 (00464371)
• Co-Investigator(Renkei-kenkyūsha): Masato Okamoto 北里大学, 薬学部, 教授 (10243718)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 口腔癌 / 癌免疫 / リンパ節転移

Outline of Final Research Achievements

We found that the sentinel lymph node expression of VEGF-C, Foxp3, CD68 and CD163 are higher than non-sentinel lymph node. And the expression of PDL1 in primary tumor with metastatic lymph node patients was higher than non lymph node metastasis patients. And we examined sera derived from OSCC patients for multiple cytokines by using a multiplexed measurement system, and the results showed that the serum IL-6 and IL-8 level tended to negatively correlate with favorable outcome in these patients disease-free survival (DFS) was significantly longer in the Stage I/II OSCC patients with low serum IL-6/8 levels compared to those with high levels.

Free Research Field

口腔外科学