Tongue allograft transplantation in dogs

2017 Fiscal Year Final Research Report

• Project/Area Number: 26463063
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Osaka University
• Principal Investigator: Isomura Emiko 大阪大学, 医学部附属病院, 助教 (70397701)
• Co-Investigator(Kenkyū-buntansha): 石濱 孝二 大阪大学, 歯学部附属病院, その他 (30432454)
• Research Collaborator: NAKAGAWA Kiyoko
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 舌 / 他家移植 / イヌ

Outline of Final Research Achievements

When complete recovery of tongue function following tumor excision is desired, reestablishment of the complex movements of the tongue is necessary, though currently available methods, such as flap or prosthesis treatment, are not sufficient. We investigated transplantation of tongue allografts along with the lingual and hypoglossal nerves, and intrinsic and extrinsic muscles of the tongue following tongue excision in beagle dogs. Allotransplantation procedures were performed with 8 pairs of sex-blind beagle dogs. A vascularized transplantation method was then used with anastomosis of the blood vessels and nerves to right side of the tongue.
Survival of the grafted tongue was noted in only 1 dog, which died 5 days after transplantation from an unknown cause.In dogs, management following transplantation is difficult. We were not able to check nerve recovery in this study, though consider that recovery of that function is important for successful tongue allograft transplantation.

Free Research Field

口腔外科