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2016 Fiscal Year Final Research Report

Role of sirtuin in volatile anesthetic-induced cardiac protection.

Research Project

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Project/Area Number 26463071
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionThe University of Tokushima

Principal Investigator

KITAHATA Hiroshi  徳島大学, 大学院医歯薬学研究部(歯学系), 教授 (60161486)

Project Period (FY) 2014-04-01 – 2017-03-31
Keywords心筋保護作用 / Sirtuin / カベオリン / プレコンディショニング / イソフルラン / 吸入麻酔薬 / 虚血再灌流障害 / 細胞膜マイクロドメイン
Outline of Final Research Achievements

Using the mouse myocardial ischemia-reperfusion model, our results show that, volatile anesthetic-induced cardiac protection is dependent on an anti-aging gene, sirtuin, and a membrane microdomain, caveolin.
Additionally, our results suggest that caveolin within the heart are critical for sirtuin-induced cardiac protection via volatile anesthetics.

Free Research Field

医歯薬学

URL: 

Published: 2018-03-22  

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