2016 Fiscal Year Final Research Report
The elucidation of the pathogenesis of the orofacial neuropathicpain and its treatment strategy
| Project/Area Number |
26463073
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Ishikawa Toshizou 山口大学, 医学部・保健学科, 教授 (90034991)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 神経障害性疼痛 / 慢性疼痛 / 神経栄養因子 / グリア細胞 |
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| Outline of Final Research Achievements |
In this study we tried to clarify how microglia cells are activated chronologically and how brain-derived neurotrophic factor relate the mechanism of pathogenesis of neuropathicpain in the central nervous system. Microglia cells are activated before developping chronic pain. The activation of microcells are decreases after developping chronic pain. The facilitation of the secretion of brain-derived neurotrophic factor did not affect the reaction latency to heat stimulation, but ameliolated depressive symptom with chronic pain.
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| Free Research Field |
歯科麻酔学
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