2016 Fiscal Year Final Research Report
Novel pharmacodynamic interactions of anesthetics: Anesthetic effects decreased or increased by herbs and supplements in the perioperative period
| Project/Area Number |
26463078
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Asahi University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 麻酔薬 / ハーブ / サプリメント / 薬力学的相互作用 / 膜作用機序 / 膜流動性 / 生体膜脂質 |
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| Outline of Final Research Achievements |
Concerning the novel pharmacodynamic interactions of anesthetics with medical herbs and botanical supplements, whether their concomotant use perioperatively affects the beneficial and adverse effects of anesthetics is experimentally addressed by focusing on biomembranes as a common site of action. Consequently, local anesthetics and general anesthetics act on biomimetic membranes to increase the membrane fluidity, whereas specific alkaloids, flavonoids and terpenoids contained in herbs and supplements decreased or increased the membrane fluidity. When used in combination, the mechanistic membrane action of anesthetics was either inhibited or enhanced, suggesting the possibility that anesthetic and cardiotoxic effects may be decreasingly or increasingly influenced through the presumable pharmacodynamic interaction.
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| Free Research Field |
応用薬理学
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