2016 Fiscal Year Final Research Report
The study of bone modeling signals mediated by periodontal stem cells under mechanical stress
| Project/Area Number |
26463089
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KANEKO Sawa 東京医科歯科大学, 歯学部, 非常勤講師 (80372449)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 歯の矯正移動 / 動物実験 / 歯根膜幹細胞 |
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| Outline of Final Research Achievements |
The response of stem cell-associated markers to orthodontic force in the periodontal ligament (PDL) in vivo is poorly understood. The aim of the study was to characterize the expression and localization of cell proliferation and osteogenic differentiation factors in the PDL during tooth movement, using Sprague-Dawley rats. Our findings suggested that orthodontic force induces Ki67 and LGR5-positive cells in the PDL in the early phase of orthodontic tooth movement.
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| Free Research Field |
歯科矯正学
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