Development of the treatment of the skeletal muscle atrophy through the IGF-1 signaling in the growth period

2016 Fiscal Year Final Research Report

• Project/Area Number: 26463095
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: The University of Tokushima
• Principal Investigator: KAWAI Nobuhiko 徳島大学, 大学院医歯薬学研究部(歯学系), 助教 (40437588)
• Research Collaborator: NOJI Sumihare ; KINOUCHI Nao ; MORI Hiroyo ; HIRASAKA Katsuya
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 骨格筋萎縮 / ユビキチンン-プロテアソーム経路 / IGF-1シグナル / Cbl-b / 機能性ペプチド

Outline of Final Research Achievements

In atrophied skeletal muscles, ubiquitin ligase, Cbl-b, increases and it stimulates the ubiquitination and degradation of IRS-1, resulting in IGF-1 resistance. In this study, we evaluate the efficacy of application of anti-ubiquitination peptide that inhibits the interaction between Cbl-b and IRS-1 into masseter muscles of C57BL/6 wild-type mice fed with soft food from 3 week old to 10 week old. Sectional area of masseter muscles treated with the peptide was larger compared to non-treated muscles. These results suggest that application of anti-ubiquitination peptide could be an effective tool for therapeutic use for muscular atrophy by maintenance of proper IGF-1 signaling.

Free Research Field

医歯薬学