2016 Fiscal Year Final Research Report
transdifferentiation mechanism of stem cells from human exfoliated deciduous teeth
| Project/Area Number |
26463106
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 歯学 / 乳歯歯髄由来間葉系幹細胞 |
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| Outline of Final Research Achievements |
In this study, we elucidated the mechanism underlying the transdifferentiation of human exfoliated deciduous teeth and conducted experiments to establish an effective bone tissue regeneration therapy using human exfoliated deciduous teeth for clinical application. When human exfoliated deciduous teeth was subcultured, we found that the number of cells expressing the surface marker of mesenchymal stem cells tended to decrease with each passage.However, activation of the Wnt signaling pathway by human exfoliated deciduous teeth antagonist increased the rate of positivity for this surface marker.
These results suggest that human exfoliated deciduous teeth could maintain plasticity as stem cells.
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| Free Research Field |
歯学
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