2016 Fiscal Year Final Research Report
Pathogenicity of hydrogen peroxide produced by oral streptococci
| Project/Area Number |
26463112
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KUWATA Hirotaka 昭和大学, 歯学部, 教授 (60380523)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ミティス群口腔レンサ球菌 / 過酸化水素 / マクロファージ / 細胞死 |
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| Outline of Final Research Achievements |
Members of the oral mitis group streptococci are dominant colonizers of dental plaque, and causative agents of infective endocarditis.
In the present study, we found that these streptococci produce hydrogen peroxide (H2O2), which is cytotoxic to human macrophages and neutrophils. The cytotoxic effect seemed to be independent of inflammatory responses, because H2O2 was not a potent stimulator of inflammatory cytokines such as TNF-a in macrophages. Our study reveals that streptococcal H2O2 plays as a cytotoxin, and is implicated in the evasion of these streptococci from host defense system by inducing cell death of innate immune cells.
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| Free Research Field |
口腔細菌学
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