Molecular differential inhibition mechanism of osteoclastic bone resorption by glucocorticoid-induced osteop orosis in childhood.

2017 Fiscal Year Final Research Report

• Project/Area Number: 26463115
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Kyushu Dental College
• Principal Investigator: Maki Kenshi 九州歯科大学, 歯学部, 教授 (60209400)
• Co-Investigator(Kenkyū-buntansha): 自見 英治郎 九州大学, 歯学研究院, 教授 (40276598)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: osteoclast / p130cas / Bif-1 / PCR / Osteoporosis

Outline of Final Research Achievements

Osteopetrosis due to dysfunction of osteoclasts in p130Cas-deficient mice suggest p130Cas play important roles for osteoclastic bone resorption. we focused Bif-1 which binding p130Cas because of the novelty, primary structure that can be involved in regulation of cytoskeleton. Western blotting and quantitative real-time PCR analysis showed the expression level of Bif-1 increased during osteoclastic differentiation. Bone mineral density of femurs isolated from Bif-1-deficient mice was higher than that of wild-type femurs using μCT analysis. These results suggest that Bif-1 is one of the candidate proteins to regulate osteoclastic bone resorption as a downstream molecule of p130Cas.

Free Research Field

小児歯科学会