Hormone therapy for childhood diabetes - effects on jawbone and long tube bone

2017 Fiscal Year Final Research Report

• Project/Area Number: 26463116
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Kyushu Dental College
• Principal Investigator: SAEKI Katsura 九州歯科大学, 歯学部, 助教 (00448812)
• Co-Investigator(Kenkyū-buntansha): 牧 憲司 九州歯科大学, 歯学部, 教授 (60209400)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 小児期糖尿病 / ホルモン療法

Outline of Final Research Achievements

We found a positive correlation between serum leptin concentration and cancellous bone mineral density in the femoral bone trunk at the initial stage of diabetes onset in model mice. Therefore, it is considered that leptin actively promotes bone mineral density in cancellous bone of the trunk of the femur in patients with early stage diabetes mellitus. On the other hand, there was no correlation between serum leptin concentration and bone mineral density in cortical bone of the femoral bone trunk or mandibular bone tissues, suggesting that the influence of leptin on undergoing membrane ossification varies depending on the site.

Free Research Field

小児歯科