Elucidation of intracerebral mechanism of stress reduction effect in amygdala by Chewing

2017 Fiscal Year Final Research Report

• Project/Area Number: 26463124
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Jichi Medical University (2015-2017); Kanagawa Dental College (2014)
• Principal Investigator: Sasaguri Kenichi 自治医科大学, 医学部, 講師 (10235286)
• Co-Investigator(Kenkyū-buntansha): 久保 金弥 名古屋女子大学, 家政学部, 教授 (00329492)
• Co-Investigator(Renkei-kenkyūsha): Yamamoto Toshiharu 神奈川歯科大学, 歯学部, 准教授 (50111901)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: Chewing / ストレス / 扁桃体 / 視床下部室傍核 / p-ERK / カイニン酸

Outline of Final Research Achievements

The aim of this study was to investigate whether or not a stressed amygdala receives chewing information and projects to the hypothalamic paraventricular nucleus to diminish the cerebral stress response.
Unilaterally ablated GABAergic neurons were induced in male rats by administering anti-GABA-transporter-1-saporin (GAT1-SAP) to the amygdala, and the effects were measured by p-ERK1/2 immunopositive cell profiles in the hypothalamic paraventricular nucleus. Results indicated that in unilaterally ablated rats, chewing’s ameliorating effects were significantly diminished in the stress-induced increase of p-ERK1/2 immunopositive cells in the ipsilateral hypothalamic paraventricular nucleus.

Free Research Field

歯科矯正学分野