Research on biomarkers for periodontitis by measuring reactive oxygen species and proteomics of sliva

2016 Fiscal Year Final Research Report

• Project/Area Number: 26463125
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Kanagawa Dental College
• Principal Investigator: Komatsu Tomoko 神奈川歯科大学, 大学院歯学研究科, 講師 (20234875)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 活性酸素 / 唾液プロテオーム / ヒスタチン / Down 症候群 / 要介護高齢者 / 歯周病

Outline of Final Research Achievements

We investigated periodontitis among young, normal healty individual, young and adult individuals with Down syndorm, and elderly with long-time care were analyzed by scavenging activity of reactive oxygen species (ROS) and proteome on sliva, respectively. Thus, we exmined the relationship between alteration of oral status and ROS scavenging activyty by suportive periodontal therapy and oral cleansing. Combined with oral and general clinical data measured by proteome and change of histatin concentration, which was antioxidant protein, on saliva, we conclued that oxidative stress would contribute to periodontitis and defencive salivary protein individuals with Down syndorm, and elderly with long-time care.

Free Research Field

障害者歯科