2016 Fiscal Year Final Research Report
A profiling of citrullination in relation to shared mechanisms in periodontitis and rheumatoid arthritis
| Project/Area Number |
26463130
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 歯周炎 / 関節リウマチ / シトルリン化 / 発症メカニズム |
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| Outline of Final Research Achievements |
The aim of the present study was to assess if the profiling of citrullination could play a role in the shared mechanisms involved in the pathogenesis of periodontitis and rheumatoid arthritis (RA). The results indicated that the serum antibody responses to peptidylarginine deiminase from Porphyromonas gingivalis (PPAD) were increased in patients with RA as compared to those without RA, which was associated with the expressions of anti-cyclic citrullinated peptide (CCP) antibodies. Additionally, the patients with low anti-PPAD titers showed a greater improvement in RA activities and anti-CCP titers after biological disease-modifying antirheumatic drug (bDMARD) therapy than the patients with high anti-PPAD titers. These results suggest the possibility that the anti-PPAD titers may be related to citrullination and RA, and also affect response to bDMARD in patients with RA.
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| Free Research Field |
歯周病学、歯周治療学
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