Relationship of periodontal infection and inflammatory cytokine to the incidence of infective endocarditis

2017 Fiscal Year Final Research Report

• Project/Area Number: 26463135
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Periodontology
• Research Institution: The University of Tokushima
• Principal Investigator: NINOMIYA Masami 徳島大学, 大学院医歯薬学研究部(歯学系), 助教 (10291494)
• Co-Investigator(Kenkyū-buntansha): 永田 俊彦 徳島大学, 大学院医歯薬学研究部(歯学系), 名誉教授 (10127847)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 感染性心内膜炎 / 心臓弁膜症 / 歯周病原細菌 / 血清抗体価 / 炎症性サイトカイン

Outline of Final Research Achievements

Infective endocarditis (IE) is a systemic septic disease in which vegetations that include bacterial clusters are formed on the endocardium and the heart valves. It is thought to be a hematogenous infection caused by oral bacteria. However, there are still many aspects that are not well understood regarding the route of infection, and the clinical evidence is still insufficient.The purpose of this study was to clarify the relationship between the progression of periodontal disease and the risk of IE, epidemiologically. The results of the study showed that patients with a history of IE had significantly more advanced resorption of the alveolar bone, fewer remaining teeth, indicating more advanced periodontal disease. Additionally, a larger percentage of these subjects had Porphyromonas gingivalis infection and serum antibody titers were higher than the reference value. These results suggest a possible association between the occurrence of IE and periodontal infections.

Free Research Field

歯周病学