2016 Fiscal Year Final Research Report
Effects of anti-gingipain drugs on periodontal diseases and systemic diseases related to periodontal medicine.
| Project/Area Number |
26463142
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Periodontology
|
|---|
| Research Institution | Health Sciences University of Hokkaido |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 歯周炎 / 関節リウマチ / 動物実験 / なた豆抽出物 / 炎症性サイトカイン |
|---|
| Outline of Final Research Achievements |
Sword Beans have been known as antipyretic agent and used as folklore medicine. In this study, we investigated anti-inflammatory effects of SBE, effects of SBE on ligature induced alveolar bone destruction, association between experimental periodontitis and rheumatoid arthritis, and effects of SBE on experimental periodontitis and rheumatoid arthritis. It was found out that intake of SBE as a drinking water reduced the alveolar bone resorption in the experimental periodontitis model rats and prevented alveolar bone resorption and inflammatory responses in the joints in experimentally induced periodontitis and rheumatoid arthritis model mouse. These effects would partly explained by the inhibitory effects of SBE on cytokine production of immunologic cells.
|
| Free Research Field |
歯周治療学
|
