The influence of diabetes for inflammatory response in periodontal tissue

2017 Fiscal Year Final Research Report

• Project/Area Number: 26463149
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Periodontology
• Research Institution: Aichi Gakuin University
• Principal Investigator: Kikuchi Takeshi 愛知学院大学, 歯学部, 准教授 (40421242)
• Co-Investigator(Kenkyū-buntansha): 三谷 章雄 愛知学院大学, 歯学部, 教授 (50329611) ; 松原 達昭 愛知学院大学, 歯学部, 教授 (30209598) ; 成瀬 桂子 愛知学院大学, 歯学部, 准教授 (30387576) ; 相野 誠 愛知学院大学, 歯学部, 講師 (20572811)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 歯周病 / 糖尿病 / 終末糖化産物 / 炎症性骨破壊

Outline of Final Research Achievements

The advanced glycation end product (AGE) did not affect the proliferative capacity of macrophages, however it was suggested the possibility of enhancing the differentiation / activation of RANKL-induced osteoclasts from macrophages at low concentrations of AGE. These possibilities may indicate part of the mechanism in the inflammatory bone destruction enhancement of periodontal disease in the diabetic environment, and those also might lead to elucidate a new mechanism concerning the influence of diabetes on periodontal disease onset and progression and identify a therapeutic target.

Free Research Field

歯周病態・診断学