The elucidation of the pathogenic activity of periodontal disease-related bacteria by metabolomics approaches; The establishment of new method to monitor their metabolic activity in real-time

2017 Fiscal Year Final Research Report

• Project/Area Number: 26463154
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Tohoku University
• Principal Investigator: Washio Jumpei 東北大学, 歯学研究科, 講師 (20400260)
• Co-Investigator(Kenkyū-buntansha): 高橋 信博 東北大学, 歯学研究科, 教授 (60183852) ; 佐藤 拓一 新潟大学, 医歯学系, 教授 (10303132) ; 小川 珠生 東北大学, 歯学研究科, 大学院非常勤講師 (40733407) ; 石黒 和子 東北大学, 歯学研究科, 大学院非常勤講師 (00755829)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: メタボローム / 代謝活性 / 歯周疾患 / 口腔細菌

Outline of Final Research Achievements

It has been suggested that the periodontal disease-related bacterial "metabolism" was strongly related to the pathogenicity of periodontal disease. However, they were still unclear because the study about their metabolism was not done enough by technical limitation. Therefore, in this KAKENHI project, I established the new method to monitor their metabolic activity easily in real-time and improved the technical method for the metabolome analysis of periodontal disease-related bacteria. The results in this study suggested that their metabolism was affected greatly by the environmental factors and drugs in actual. These new methods and knowledges could contribute to elucidate the onset mechanism of periodontal diseases and the development of new strategy for their treatment and prevention.

Free Research Field

口腔生化学、予防歯科学