2016 Fiscal Year Final Research Report
Development of a genetic test for Streptococcus sobrinus
| Project/Area Number |
26463159
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 歯学 / ミュータンスレンサ球菌 / 齲蝕 |
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| Outline of Final Research Achievements |
Streptococcus sobrinus possesses a high ability to produce water-insoluble glucan (WIG), that contributes to accumulation on tooth surface and subsequent dental caries. This bacterium produces GtfI enzyme coded by gtfI gene that synthesizes WIG. We analyzed the association between WIG synthesis by clinical isolates of S. sobrinus and variation in the base sequence of gtfI gene. Relatively large numbers of missense mutations were observed in dextran-binding domain that is located in 3' end side of gtfI gene. We found that an isolate of S. sobrinus with one of the missense mutations in the dextran-binding domain showed particularly high WIG synthesis ability.
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| Free Research Field |
予防歯科学
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