Developing an objective method for diagnosing periodontal inflammation using saliva.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26463164
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Social dentistry
• Research Institution: The University of Tokushima
• Principal Investigator: FUKUI Makoto 徳島大学, 大学院医歯薬学研究部(歯学系), 助教 (50325289)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 唾液 / バイオマーカー / サイトカイン / 歯肉炎

Outline of Final Research Achievements

Saliva contains many bioactive substances, and holds promise for use in clinical tests thanks to its ability to be sampled conveniently and non-invasively compared with blood. In this study, the concentration ranges of bioactive substances in saliva sampled from periodontally healthy or gingivitis patients were determined and analyzed in detail to develop a novel technique for diagnosing periodontal inflammation using saliva specimens. Saliva and gingival crevicular fluid (GCF) were collected from healthy adults, with periodontal tissue ranging in condition from healthy to gingivitis. Relations were characterized between the concentration ranges of several biomarkers, the abundance ratios and concentration ranges of salivary cytokines, and periodontal inflammatory state. The basic research data obtained will help to develop new saliva or GCF-based procedures for use in health check-ups.

Free Research Field

予防歯科学