2016 Fiscal Year Final Research Report
Effects of Hydrogen-rich water on aphthous stomatitis
| Project/Area Number |
26463172
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Social dentistry
|
|---|
| Research Institution | Nihon University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 水素水 / 口内炎モデルラット / 口内炎 / 口腔粘膜炎 / 抗酸化物質 |
|---|
| Outline of Final Research Achievements |
Hydrogen (H2) water may be applied to prevent the stomatitis since it inhibits the inflammation via decrease in interleukin 6 (IL6). We established the new rat model of the stomatitis and researched the effect of H2 water on the stomatitis using its model. The stomatitis was induced on the rat tongue. H2 or de-H2 water were applied to the rat for 8 days since a week ago of stomatitis induction. At 24 h after the stomatitis induction, mRNA levels of the inflammatory cytokines were measured by the real-time PCR. IL6 mRNA level was decreased by the treatment of H2 water.
|
| Free Research Field |
衛生学公衆衛生学 予防歯科学
|
