2016 Fiscal Year Final Research Report
Promotive activity to alveolar bone resorption by Cd in tobacco:Differention and bone resorption activity in osteoclasts
| Project/Area Number |
26463177
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | The Nippon Dental University College at Tokyo |
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Principal Investigator |
SATO TSUTOMU 日本歯科大学東京短期大学, その他部局等, 教授(移行) (60130671)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | タバコ / カドミウム / 歯周病 / 骨代謝 |
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| Outline of Final Research Achievements |
Tobacco contains many harmful substances. Cadmium(Cd) which is known as the cause of Itai-itai disease is also present in comparatively high concentration. Periodontal disease is an infectious disease caused by periodontal bacteria living in the oral cavity, however, the onset and progression of the disease are deeply inflenced by various habits and lifestyle choices, among which smoking is one of the most important risk facors. The objective of the present study was to examine the correlation Cd in tobacco and alvelar bone resorption occured in periodontal disease using both human osteoblasts and pre-osteoclasts in vitro. As a result, Cd had effected on cellular functions. These results suggested that smorker was high risk person to periodontal disease.
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| Free Research Field |
衛生学
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