2016 Fiscal Year Final Research Report
A new treatment for metabolic syndrome with references to fructose metabolism
| Project/Area Number |
26500005
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Gifu University |
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Principal Investigator |
Iizuka Katsumi 岐阜大学, 医学部附属病院, 講師 (40431712)
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| Research Collaborator |
KATO Takehiro
TAKAO Ken
NIWA Hiroyuki
WU Wudelehu
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ChREBP / フルクトース / 小腸 / GLUT5 / ケトヘキソキナーゼ / 肝臓 / ブドウ糖 |
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| Outline of Final Research Achievements |
Excess intake of fructose is reported to cause dysmetabolic syndrome. We studied the role of glucose activated transcription factor, ChREBP, in fructose metabolism. We identified that ChREBP induces genes expression related to fructose metabolism and thereby promotes fructose uptake and its breakdown in intestine and conversion into other metabolites in liver. Fructose (Fruit sugar) has more potent cytotoxicity because of increased advanced glycation end product (AGE) production. This study showed that intestinal and hepatic ChREBP function has an important role in protecting from fructose toxicity.
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| Free Research Field |
代謝学、栄養学、糖尿病学、内分泌代謝学
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