Clarification of molecular mechanism of calcification and development to CKD nutritional therapy by correlation of bone and vascular

2016 Fiscal Year Final Research Report

• Project/Area Number: 26500012
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Integrated Nutrition Science
• Research Institution: University of Hyogo
• Principal Investigator: ITO MIKIKO 兵庫県立大学, 環境人間学部, 教授 (50314852)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 血管石灰化 / 慢性腎蔵病 / 高リン血症

Outline of Final Research Achievements

Vascular calcification is a risk factor for cardiovascular events in chronic kidney disease (CKD) patients. In order to develop nutritional therapy for suppressing vascular calcification, we examined to clarify the phosphate regulation by bone-vessel interaction. In this study, we searched candidate molecule that function in phosphate regulation in both bone and vessel and then we analyzed the function in vitro and in vivo. The candidate molecule expression increased after differentiation of osteoclasts and calcification of vascular smooth muscle cells. In CKD model rat, the candidate molecule expressed at calcification area in vascular aorta. Thus, it was indicated that this molecule is likely to be involved in calcification. We will further research the function and relation with nutrition in the future, and will lead to the developing of nutrition therapy.

Free Research Field

臨床栄養学