Biological backgfound of polyamine-induced life-span extension of mammals

2016 Fiscal Year Final Research Report

• Project/Area Number: 26500015
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Integrated Nutrition Science
• Research Institution: Jichi Medical University
• Principal Investigator: Soda Kuniyasu 自治医科大学, 医学部, 教授 (00221341)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 生活習慣病 / 老化 / アンチエイジング / ポリアミン / スペルミン / 遺伝子メチル化 / 遺伝子修飾 / 健康長寿食

Outline of Final Research Achievements

Many experiments have shown that mammalian life-span extension cannot be attained by ingestion of the so-called antioxidants, such as polyphenols contained in healthy macrobiotic foods such as legumes and vegetables and in macrobiotic dietary pattern such as Mediterranean diet. We have reported that the polyamines (spermine and spermidine) contained in so-called healthy macrobiotic diet such as legumes, vegetables, mushrooms, fishes, and shellfishes, and the healthy macrobiotic diet pattern such as Mediterranean diet and the Japanese food extends life-span of mice. The purpose of the study is to unveil the biological background of polyamine-induced mammalian life-span extension. As a result, we found that, in addition to biological activities such as an anti-inflammation, an antioxidant action, a gene protective action, etc., polyamine inhibits abnormal gene methylation associated with aging and aging associated pathologies.

Free Research Field

アンチエイジング医学