2016 Fiscal Year Final Research Report
Molecular mechanism for the sex difference in learning ability by feeding environment
| Project/Area Number |
26500017
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 性差 / 環境 / 学習機能 / 海馬 / AMPA受容体サブユニット / シナプス / 記憶 |
|---|
| Outline of Final Research Achievements |
Powded pellet diet enhanced hippocampus-related brain higher functions such as learning ability only in female rats. This molecular basis was revealed by electrophysiological and biochemical experiments that the functional changes in the AMPA receptor subunit composition which was associated with learning ability. Also, powdred pellet enhanced synaptic function in the hippocampus. These changes were related to estrogen.
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| Free Research Field |
生理学
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