2016 Fiscal Year Final Research Report
Development of new remote sampling ionization method for endoscopic mass spectrometry
| Project/Area Number |
26505003
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
オミクス計測科学
|
|---|
| Research Institution | University of Yamanashi |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 質量分析 / 内視鏡診断 / 大気圧イオン源 / 遠隔採取 |
|---|
| Outline of Final Research Achievements |
At present, endoscopy relies almost exclusively on optical microscopy and the accurate analysis such as MS interrogation is performed ex-situ using biopsy. In this work, a novel probing system is developed to perform an in-situ and in-vivo endoscopic mass spectrometry using a moving string for the sampling and transportation of material. The sampling system consists of a moving cotton thread driven by motorized pulleys. When the target surface is touched by the sampling probe, the cotton thread “wipes” and transports the adhered sample to the ion source. Depending on the target analytes, desorption electrospray and atmospheric pressure chemical ionization sources are employed interchangeably for the desorption and ionization.The surface under analysis is not subjected to heat, organic solvents, high voltage or charged droplets. In-situ endoscopic MS of a living mouse and the surface analysis inside a volunteer subject’s mouth are successfully demonstrated.
|
| Free Research Field |
質量分析
|
