Metallomics imaging analysis technology in living organisms by bio-metal analysis and molecular imaging technologies

2017 Fiscal Year Final Research Report

• Project/Area Number: 26505014
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: オミクス計測科学
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Motomura Shinji 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, 副チームリーダー (20360654)
• Research Collaborator: IDA Takahiro
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: コンプトンカメラ / 3次元断層画像 / ガンマ線イメージイング / 3次元定量撮像法 / 生体メタロミクス計測

Outline of Final Research Achievements

We made it possible to obtain three-dimensional (3D) tomographic images of the behaviors of multiple radionuclides administered to a living mouse by semiconductor Compton camera GREI with improved quanlitativity, to realize　a new metallomics measurement technology that performs imaging analysis of the behaviors of various metal elements and associated biomolecules in living organisms. We applied the technology to the GREI data of Sr-85, Mn-54 and Zn-65 simultaneously administered to a diabetes mellitus model mouse, and succeeded in visualizing the characteristic behavior of Sr-85 in the 3D image clearly, and obtaining the 3D image of Mn-54 that suggested the similar behavior as that of Sr-85. In addition to that, we came up with a new metallomics imaging diagnosis method that takes the GREI images of the radioisotopes of Na and K administered simultaneously.

Free Research Field

放射線計測学、ガンマ線分光学、分子イメージング