2016 Fiscal Year Final Research Report
Muscle memory in space environment to be elucidated by epigenetics.
| Project/Area Number |
26506021
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
宇宙生命学
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 微小重力環境 / ヒストン修飾 / 遺伝子発現 / エピジェネティクス |
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| Outline of Final Research Achievements |
This study aimed to examine the effect of long-term exercise training and physical inactivity on hindlimb unloading-induced muscle atrophy in the rat soleus muscle. Our data reveals that long-term physical inactivity increases the trimethylation of lysine residue 9 of histone H3, whereas regular physical exercise training decreases it in the rat soleus muscle. Although exercise training didn’t completely prevent hindlimb unloading-induced muscle atrophy, the trimethylation of lysine residue 9 of histone H3 and E3 ligase mRNA levels were downregulated by physical exercise training. These observations indicate that physical exercise training partly attenuates hindlimb unloading-induced disuse muscle atrophy in the rat soleus muscle. This might be mediated by downregulation of trimethylation of lysine residue 9 of histone H3 and muscle atrophy-related gene expression.
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| Free Research Field |
骨格筋生化学
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