2016 Fiscal Year Final Research Report
The acquisition methods for radiation-resistance by means of light irradiation.
| Project/Area Number |
26506022
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
宇宙生命学
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| Research Institution | Tokai University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ROS / TRPチャネル / 分子シャペロン / HSP-70 |
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| Outline of Final Research Achievements |
Succeeding irradiation of radioactive or cosmic ray induces intracellular reactive oxygen species (ROS). ROS production promotes cellular and genetic oxidative damages, thus apoptosis has occurred. On the other hand intermittent light irradiation even though the total radiation energy is identical as the succeeding irradiation, produces intracellular molecular chaperons which is effective on restoration of the cellular protein damages. This process produces the radiation-resistant characteristics. Heat shock protein-70 (HSP-70) is the one of the molecular chaperon, activated through the elevation of intracellular calcium then activating transient receptor potential (TRP). This working hypothesis has been examined with human primary keratinocytes and human dermal fibroblasts.
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| Free Research Field |
生物物理学、神経科学
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