Changes of cardiovascular parameters after postural transition and its regulation according to the development and aging

2017 Fiscal Year Final Research Report

• Project/Area Number: 26506024
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 宇宙生命学
• Research Institution: Fujita Health University
• Principal Investigator: YAMASAKI Masao 藤田保健衛生大学, 保健学研究科, 教授 (10192395)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 血圧 / 圧受容器反射 / 体位変換 / Head-up Tilt / 自律神経 / 老化 / 体液シフト / ラット

Outline of Final Research Achievements

The intravascular pressure involved with hydrostatic pressure, and its pressure gradient changes and/or differences due to postural transition and posture. These changes lead mainly the arterial baroreceptor reflex (BR) to maintain the Systemic Arterial Pressure: SAP, in other word blood perfusion pressure, contributing the blood supply to brain. The changes of SAP, common carotid arterial flow as blood supply toward head and heat rate (HR) after and during Head-up tilt (HUT) ware examined. These results indicated that the cardiovascular parameters after onset of 30 min HUT fluctuated relatively and the SAP was not maintained well through HUT in un-mature and elder rats compared with mature, suggesting the BR was weaker according to the aging.

Free Research Field

循環生理学　自律神経