Pathophysiological analysis of sleep-disordered breathing toward building the individualized treatment.

2017 Fiscal Year Final Research Report

• Project/Area Number: 26507011
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 睡眠科学
• Research Institution: Tokyo Medical University
• Principal Investigator: Hideaki Nakayama 東京医科大学, 医学部, 准教授 (30444144)
• Co-Investigator(Kenkyū-buntansha): 瀬戸口 靖弘 東京医科大学, 医学部, 兼任助教 (90206649)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 睡眠呼吸障害 / 呼吸調節 / 覚醒閾値

Outline of Final Research Achievements

Sleep-disordered breathing (SDB) is the multifactorial disorder including upper airway collapsibility, breathing instability and arousability. We tried to establish the way to evaluate these factors and to classify pathophysiological traits. In obese patients with SDB, anatomical upper airway narrowing is the most important factor. Therefore, in non-obese patients, it is more efficient to evaluate functional upper airway collapsibility in addition to breathing instability and arousability. Actually, because this method is time-spending and effort-dependent, we need to develop the simpler and more reliable way on the clinical base.

Free Research Field

睡眠呼吸障害